> Home > Research

  1. Megan Carey
    Neural Circuits and Behavior


    Eugenia Chiappe
    Sensorimotor Integration


    Rui Costa
    Neurobiology of Action


    Bruno Costa-Silva
    Systems Oncology


    Gonzalo de Polavieja
    Collective Behavior


    Susana Lima
    Neuroethology


    Christian Machens
    Theoretical Neuroscience


    Zachary Mainen
    Systems Neuroscience


    Marta Moita
    Behavioral Neuroscience


    Eduardo Moreno
    Cell Fitness


    Michael Orger
    Vision to Action


    Joe Paton
    Learning


    Leopoldo Petreanu
    Cortical Circuits


    Alfonso Renart
    Circuit Dynamics & Computation


    Christa Rhiner
    Stem cells and regeneration


    Carlos Ribeiro
    Behavior and Metabolism


    Adriana Sánchez Danés
    Cancer and Stem Cell Biology


    Noam Shemesh
    Neuroplasticity and Neural Activity


    Maria Luísa Vasconcelos
    Innate Behavior


    Henrique Veiga-Fernandes
    Immunophysiology


  1. Systems Neuroscience



    We do not perceive the world directly. Rather, our brains must decipher what is out there using the window of information we receive from our senses. The result of this process is referred to as a ‘model’ of the world. Understanding how brains construct and use internal models is a central problem in neuroscience. This problem can be approached by thinking of the brain as a kind of an intuitive scientist, collecting and analysing data, constructing and testing hypotheses based on those data, and revising them in light of new data. Each brain gets different data and produces a different model, making the beliefs that guide our actions subjective and sometimes wrong. Fortunately, like a good scientist, our brains can and do evaluate the quality of the data. This gives us a sense of confidence in our beliefs and decisions, helping us to know when our subjective reality is worth acting on and when to question it. Understanding how all this works in terms of neural circuits is the long-term goal of research in the Systems Neuroscience lab. 

Latest Publications

  • Pardo-Vazquez JL, Castiñeiras-de Saa JR, Valente M, Damião I, Costa T, Vicente MI, Mendonça AG, Mainen ZF, Renart A (2019) The mechanistic foundation of Weber's law Nat. Neurosci. 22 (9)
  • Maia, A.; Oliveira, J.; Lajnef, M.; Mallet, L.; Tamouza, R.; Leboye, M.; Oliveira-Maia, A. J. (2019) Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis Acta Psychiatr Scand
  • Brugada-Ramentol, Victoria; Clemens, Ivar; de Polavieja, Gonzalo G. (2019) Active control as evidence in favor of sense of ownership in the moving Virtual Hand Illusion
  • Rao-Ruiz, Priyanka; Couey, Jonathan J.; Marcelo, Ivo M.; Bouwkamp, Christian G.; Slump, Denise E.; Matos, Mariana R.; van der Loo, Rolinka J.; Martins, Gabriela J.; van den Hout, Mirjam; van IJcken, Wilfred F.; Costa, Rui M.; van den Oever, Michel C.; Kus (2019) Engram-specific transcriptome profiling of contextual memory consolidation Nat Commun
  • Huber, Elizabeth; Henriques, Rafael Neto; Owen, Julia P.; Rokem, Ariel; Yeatman, Jason D. (2019) Applying microstructural models to understand the role of white matter in cognitive development