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  1. Molecular and Transgenic Tools Platform


    The Molecular and Transgenic Tools (MTT) Platform performs complex animal and tissue transgenic and gene editing projects by providing researchers with support in Molecular Biology techniques, from basic services such as the production of competent bacterial cells or primer design, to complex clonings of knock-out and knock-in constructs to be delivered into cells/tissues or embryos of model animals such as zebrafish, fly or mouse. It works in close collaboration with the animal platforms managing full projects from the conceptual design to the transgenic/mutant animal delivery.
    The MTT Platform also encompasses a Vector Production (VP) service to support research by producing viral vectors widely used in either established or newly developing techniques. It also aspires to introduce viral vectors as a gene delivery tool into new research areas.
    It acts as a hub of shared resources and expertise for the entire institutional and national research communities by achieving cost-minimizing objectives by avoiding duplication of reagents, equipment and personnel.

Latest Publications

  • Maia, A.; Oliveira, J.; Lajnef, M.; Mallet, L.; Tamouza, R.; Leboye, M.; Oliveira-Maia, A. J. (2019) Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis Acta Psychiatr Scand
     
  • Brugada-Ramentol, Victoria; Clemens, Ivar; de Polavieja, Gonzalo G. (2019) Active control as evidence in favor of sense of ownership in the moving Virtual Hand Illusion
     
  • Rao-Ruiz, Priyanka; Couey, Jonathan J.; Marcelo, Ivo M.; Bouwkamp, Christian G.; Slump, Denise E.; Matos, Mariana R.; van der Loo, Rolinka J.; Martins, Gabriela J.; van den Hout, Mirjam; van IJcken, Wilfred F.; Costa, Rui M.; van den Oever, Michel C.; Kus (2019) Engram-specific transcriptome profiling of contextual memory consolidation Nat Commun
     
  • Huber, Elizabeth; Henriques, Rafael Neto; Owen, Julia P.; Rokem, Ariel; Yeatman, Jason D. (2019) Applying microstructural models to understand the role of white matter in cognitive development
     
  • Kobak, Dmitry; Pardo-Vazquez, Jose L.; Valente, Mafalda; Machens, Christian K.; Renart, Alfonso (2019) State-dependent geometry of population activity in rat auditory cortex eLife