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  1. Cell Fitness

    Humans are able to detect fitness decay in colleagues by looking at the graying of the hair or the wrinkles in their faces. Work from my laboratory in the last few years has shown that cells can also detect fitness levels of neighboring cells using a molecular code. Those “fitness fingerprints” (Rhiner et al., Dev.Cell, 2010; Merino et al., Curr. Biol., 2013) can be used to mediate cell selection by recognizing and eliminating less fit cells during ageing (Merino et al., Cell, 2015), regeneration (Moreno et al., Curr. Biol., 2015) and cancer (Levayer et al., Nature 2015).

Key publications

  • Dina S. Coelho, Silvia Schwartz, Marisa M. Merino, Barbara Hauert, Barbara Topfel, Christa Rhiner and Eduardo Moreno (2018) Culling less fit neurons protects against amyloid-Beta-induced brain damage and cognitive and motor decline Cell Rep
  • Levayer R, Dupont C, Moreno E. (2016) Tissue Crowding Induces Caspase-Dependent Competition for Space. Curr. Biol. S0960-9822 (16), 00059-2
  • Merino MM, Levayer R, Moreno E (2016) Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer Trends Cell Biol.
  • Levayer, R., Hauert, B. and Moreno, E (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction Nature
  • Merino MM, Rhiner C, Lopez-Gay JM, Buechel D, Hauert B, Moreno E (2015) Elimination of unfit cells maintains tissue health and prolongs lifespan Cell
  • Merino MM, Rhiner C, Portela M, Moreno E (2013) "Fitness fingerprints" mediate physiological culling of unwanted neurons in Drosophila Curr. Biol.
  • Moreno, E. (2012) Design and Construction of ‘‘Synthetic Species’’ PLoS ONE
  • Rhiner C, López-Gay JM, Soldini D, Casas-Tinto S, Martín FA, Lombardía L, Moreno E (2010) Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila Dev. Cell
  • Moreno, E. (2008) Is cell competition relevant to cancer? Nat. Rev. Cancer
  • Moreno E, Basler K (2004) dMyc transforms cells into super-competitors Cell
  • Moreno E, Basler K, Morata G (2002) Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development Nature