The nervous system is composed of a large variety of neuronal and glial cell types appropriately connected to reliably perform its functions, such as those sustaining basic survival (e.g. breathing) and behavioural responses to internal and external stimuli. We are currently focusing our work in the understanding of neural circuit formation during development and for this we are using the zebrafish larva as an animal model. We are particularly interested on the intersection of circuit formation and neuronal activity such as the role played by neuronal activity in circuit establishment and selection.

We work in collaboration with the Orger and de Polavieja groups.

Analysis of neuronal subpopulations in development using Gal4 lines and immnohystochemistry

Analyse neuronal subpopulations in development using Gal4 lines and immnohystochemistry

Imaging of neuronal circuit development

Identify specific circuits amenable to whole circuit development imaging

Ruth Diez del Corral, PhD
Research Associate
ruth.diezdelcorral@neuro.fchampalimaud.org

Biography

Mariana Viegas
Masters Student
mariana.viegas@research.fchampalimaud.org

Ruth Diez del Corral, Aixa V. Morales (2017) The Multiple Roles of FGF Signaling in the Developing Spinal Cord Front. Cell Dev. Biol. 5:58 (doi:https://doi.org/10.3389/fcell.2017.00058)

Morales AV, Espeso-Gil S, Ocaña I, Nieto-Lopez F, Calleja E, Bovolenta P, Lewandoski M, Diez Del Corral R. (2016) FGF signaling enhances a sonic hedgehog negative feedback loop at the initiation of spinal cord ventral patterning Dev Neurobiol (doi:10.1002/dneu.22368)

Quiroga, A. C., Stolt, C. C., Diez del Corral, R., Dimitrov, S., Pérez-Alcalá, S., Sock, E., Barbas, J. A., Wegner, M. and Morales, A. V. (2014) Sox5 controls dorsal progenitor and interneuron specification in the spinal cord Dev Neurobiol (doi: doi: 10.1002/dneu.22240)

Martínez-Morales PL, Diez del Corral R, Olivera-Martínez I, Quiroga AC, Das RM, Barbas JA, Storey KG, Morales AV (2011) FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk J. Cell Biol. 194 (3), 489-503 (doi:10.1083/jcb.201011077)