The interplay between diet, immune cells and intestinal microbes ensures vital functions of the organism, such as energy and micronutrient extraction from the diet, protection from pathogenic microbes and maintenance of a healthy epithelial barrier. These complex networks are of vital importance to organismic homeostasis, while inadequate relationships can lead to cancer and chronic inflammatory diseases, which are major Public Health concerns.
Adaptive immune lymphocytes express recombining antigen-specific receptors. These lymphocytes are activated by defined antigens and require a differentiation phase before exerting their effector function. In contrast, innate lymphocytes display rapid effector functions despite their set of limited germ-line encoded receptors. A mounting body of evidence indicates that in addition to their well-established developmentally regulated program, immune cells are also controlled by dietary signals and neuronal inputs. Thus, although there is tangible evidence suggesting that immune cells possess unexpected sensing strategies, how lymphoid cells perceive, integrate and respond to environmental cues remains poorly understood and vastly unexplored.
We centre our efforts on defining lymphocyte sensory mechanisms in health and disease. We use an integrative across-level approach aiming to elucidate the tenets of lymphocyte sensing and communication, within, across and beyond the organism.

Overview

Our long-term goal is to understand sensory and communication pathways that determine immune cell fate and disease progression. To achieve this, we centre our efforts at mucosal barriers that constitute the largest interface of the body with the external environment. Epithelial barriers line body surfaces and grant safeguard against harmful pathogens but are frequent targets of oncologic transformation and chronic inflammatory diseases. In this context, we tackle the following hitherto elusive points:

Micronutrient sensing by lymphocytes

We aim to unravel the mechanisms by which micronutrients control mucosal lymphocytes and their interaction with the epithelial barrier and microbiota.

Multi-tissue sensors

We focus on novel sensing programs by which lymphocytes integrate neuron and neuroglia cues, defining key multi-cellular units at the core of mucosal physiology in health and disease.

Neuronal circuits and circadian inputs

We focus on how neuronal circuits and their inputs regulate immune functions in the context of chronic inflammation and cancer.

Henrique Veiga-Fernandes, PhD
Principal Investigator
henrique.veigafernandes@research.fchampalimaud.org

Biography

David Brea Lopez, PhD
Postdoctoral Researcher
david.brealopez@research.fchampalimaud.org

Inês Godinho
Technician
ines.godinho@research.fchampalimaud.org

Kristin Fischer
2017 INDP PhD Student
kristin.fischer@research.fchampalimaud.org

María Martínez-Lopez, PhD

maria.martinezlopez@research.fchampalimaud.org

Marko Šestan, PhD
Postdoctoral Researcher
marko.sestan@research.fchampalimaud.org

Roeland Klein Wolterink, MD, PhD
Postdoctoral Researcher
roel.kleinwolterink@research.fchampalimaud.org

Roksana Pirzgalska, PhD
Postdoctoral Researcher
roksana.pirzgalska@research.fchampalimaud.org

Telmo Catarino
External PhD Student
telmo.catarino@research.fchampalimaud.org

Lab Administration

Hélder Ribeiro
Lab Manager
helder.ribeiro@research.fchampalimaud.org

Telma Carrilho
Lab Administrator
telma.carrilho@research.fchampalimaud.org

PhD Student

Ana Filipa Cardoso
External PhD Student
ana.cardoso@research.fchampalimaud.org

Rita Domingues
External PhD Student
rita.domingues@research.fchampalimaud.org

Sílvia Madeira
External Student
silvia.madeira@research.fchampalimaud.org

Vânia Cardoso
PhD Student
vania.cardoso@research.fchampalimaud.org

Postdoctoral Fellow

Cristina Godinho da Silva, PhD
Postdoctoral Researcher
cristina.silva@research.fchampalimaud.org

Julie Chesné, PhD
Postdoctoral Researcher
julie.chesne@research.fchampalimaud.org

Manuela Ferreira, PhD
Postdoctoral Researcher
manuela.ferreira@research.fchampalimaud.org

Technician

Bruno Raposo
Research Technician
bruno.raposo@research.fchampalimaud.org

Miguel Rendas
Research Technician
miguel.rendas@research.fchampalimaud.org

Sara Correia
Technician
sara.correia@research.fchampalimaud.org

Veiga-Fernandes H and Artis D. (2018) Neuronal-immune system cross-talk: a new paradigm in physiology Science (doi:10.1126/science.aap9598)

Chesné J; Cardoso V; Veiga-Fernandes H. (2018) Neuro-immune regulation of mucosal physiology (doi:10.1038/s41385-018-0063-y)

Godinho-Silva C; Cardoso F; Veiga-Fernandes H (2018) Neuro-Immune Cell Units: A New Paradigm in Physiology (doi:10.1146/annurev-immunol-042718-041812)

Emgard J; Kammoun H; García-Cassani B; Chesné J; Parigi SM; Jacob JM; Cheng HW; Evren E; Das S; Czarnewski P; Sleiers N; Melo-Gonzalez F; Kvedaraite E; Svensson M; Scandella E; Hepworth MR; Huber S; Ludewig B; Peduto L; Villablanca EJ; Veiga-Fernandes H; (2018) Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation (doi:10.1016/j.immuni.2017.11.020)

Klein Wolterink RGJ; Pirzgalska RM; Veiga-Fernandes H (2018) Neuroendocrine Cells Take Your Breath Away (doi:10.1016/j.immuni.2018.06.010)

Cardoso V, Chesné J, Ribeiro H, García-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H (2017) Neuronal regulation of type 2 innate lymphoid cells via neuromedin U Nature 549 (7671), 277-281 (doi:10.1038/nature23469)

Veiga-Fernandes H, Freitas AA (2017) The S(c)ensory Immune System Theory Trends in Immunology (doi:10.1016/j.it.2017.02.007)

Veiga-Fernandes H, Pachnis V (2017) Neuroimmune regulation during intestinal development and homeostasis Nat Immunol 18 (2), 116-122 (doi:10.1038/ni.3634)

Mowel WK; McCright SJ; Kotzin JJ; Collet MA; Uyar A; Chen X; DeLaney A; Spencer SP; Virtue AT; Yang EJ; Villarino A; Kurachi M; Dunagin MC; Pritchard GH; Stein J; Hughes C; Fonseca-Pereira D; Veiga-Fernandes H; Raj A; Kambayashi T; Brodsky IE; O'Shea JJ; (2017) Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA (doi:10.1016/j.immuni.2017.08.012)

S M Fernandes; A R Pires; P Matoso; C Ferreira; H Nunes-Cabaço; L Correia; E Valadas; J Poças; P Pacheco; H Veiga-Fernandes; R B Foxall & A E Sousa (2017) HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication (doi:10.1038/mi.2017.44)

Ibiza S, García-Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, Misic AM, Bartow-McKenney C, Larson DM, Pavan WJ, Eberl G, Grice EA, Veiga-Fernandes H. (2016) Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence Nature 535 (7612), 440–443 (doi:10.1038/nature18644)

Veiga-Fernandes H, Mucida D. (2016) Neuro-Immune Interactions at Barrier Surfaces. Cell 165 (4), 801-811 (doi:10.1016/j.cell.2016.04.041)

Veldhoen M, Veiga-Fernandes H (2015) Feeding immunity: skepticism, delicacies and delights. Nat Immunol 16 (3), 215-219 (doi:10.1038/ni.3100)

Fonseca-Pereira, D., Arroz-Madeira, S., Rodrigues-Campos, M., Barbosa, I., Domingues, R.G., Bento, T., Almeida, A.R.M., Ribeiro, H., Potocnik, A., Enomoto, H. and Veiga-Fernandes, H. (2014) The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function Nature 514(7520) , 98-10 (doi:10.1038/nature13498)

Klose CS, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, Fabiunke C, Pfeifer D, Sexl V, Fonseca-Pereira D, Domingues RG, Veiga-Fernandes H7, Arnold SJ, Busslinger M, Dunay IR, Tanriver Y, Diefenbach A. (2014) Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages. Cell 157 (2), 340-356 (doi:10.1016/j.cell.2014.03.030)

van de Pavert, S. A., M. Ferreira, R. G. Domingues, H. Ribeiro, R. Molenaar, L. Moreira-Santos, F. F. Almeida, S. Ibiza, I. Barbosa, G. Goverse, C. Labao-Almeida, C. Godinho-Silva, T. Konijn, D. Schooneman, T. O'Toole, M. R. Mizee, Y. Habani, E. Haak, F. (2014) Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 508 , 123-127 (doi:10.1038/nature13158)

Veiga-Fernandes, H., Coles, M.C., Foster, K.E., Patel, A., Williams, A., Natarajan, D., Barlow, A., Pachnis, V. and Kioussis, D. (2007) Tyrosine kinase receptor Ret is a key regulator in Peyer’s Patch organogenesis. Nature 446(7135) , 547-51 (doi:10.1038/nature05597)