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  1. Circuit Dynamics & Computation



    We are interested in identifying generic principles governing the dynamics of cortical circuits and the way in which they produce function. Our current work evolves around two lines of research: sensory perception in the auditory modality – with an emphasis on the relationship between the response variability of sensory neurons and the accuracy of perceptual discriminations – and working memory, with a focus on the mechanisms underlying the maintenance of information across time in the prefrontal cortex. Our research strategy relies both on identifying characteristic signatures of population organization – through recordings of the simultaneous activity of neuronal populations during controlled behavioral tasks – as well as on developing a mechanistic understanding of how these patterns of population activity emerge – which we investigate by developing mathematical models of the underlying neuronal circuits.

Latest Publications

  • Rao-Ruiz, Priyanka; Couey, Jonathan J.; Marcelo, Ivo M.; Bouwkamp, Christian G.; Slump, Denise E.; Matos, Mariana R.; van der Loo, Rolinka J.; Martins, Gabriela J.; van den Hout, Mirjam; van IJcken, Wilfred F.; Costa, Rui M.; van den Oever, Michel C.; Kus (2019) Engram-specific transcriptome profiling of contextual memory consolidation Nat Commun
  • French, Catherine A.; Vinueza Veloz, Maria F.; Zhou, Kuikui; Peter, Sasa; Fisher, Simon E.; Costa, Rui M.; De Zeeuw, Chris I. (2019) Conditional disruption of Foxp2 in the mouse brain Mol. Psychiatry
  • Riahi, Human; Brekelmans, Carlijn; Foriel, Sarah; Merkling, Sarah H.; Lyons, Taylor A.; Itskov, Pavel M.; Kleefstra, Tjitske; Ribeiro, Carlos; van Rij, Ronald P.; Kramer, Jamie M.; Schenck, Annette (2019) The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption PLoS Biol.
  • Inês Santiago, João Santinha, Andrada Ianus, Antonio Galzerano, Rita Theias, Joana Maia, Maria Joao Barata, Nuno Loução, Bruno Costa-Silva, Antonio Beltran, Celso Matos and Noam Shemesh (2019) Susceptibility perturbation MRI (SPI) maps tumor infiltration into mesorectal lymph nodes Can Res
  • Rodriguez-Ruiz, Claudia; Munoz-Reyes, Jose Antonio; Iglesias-Julios, Marta; Sanchez-Pages, Santiago; Turiegano, Enrique (2019) Sex Affects the Relationship Between Third Party Punishment and Cooperation Sci Rep