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Eduardo Moreno

  1. Eduardo Moreno, PhD
    Principal Investigator
    eduardo.moreno@research.fchampalimaud.org

  2. I was born and studied molecular biology in Madrid. I did my PhD on homeotic genes at the laboratory of Gines Morata in the Molecular Biology Center Severo Ochoa in Madrid. After my PhD I stayed one more year in Gines Morata´s lab to start the molecular and genetic study of cell competition. I then took that project with me to do a postdoc in Zurich in the laboratory of Konrad Basler. In 2005 I started my own lab in Madrid at the Spanish National Cancer Center (CNIO) where my team and I discovered the existence of fitness fingerprints in the surface of animal cells in the context of research funded by a ERC starting grant. Since 2011 until 2016 I was a Professor and group leader at the IZB of the University of Bern, where I was awarded an ERC consolidator grant to study the molecular mechanisms of cell selection based on "fitness fingerprints" during development, cancer, ageing and neurobiology. Since 2016 I am a group leader at the Champalimaud Research Programme.

Key publications

  • Levayer R, Dupont C, Moreno E. (2016) Tissue Crowding Induces Caspase-Dependent Competition for Space. Curr. Biol. S0960-9822 (16), 00059-2
     
  • Merino MM, Levayer R, Moreno E (2016) Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer Trends Cell Biol.
     
  • Levayer, R., Hauert, B. and Moreno, E (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction Nature
     
  • Merino MM, Rhiner C, Lopez-Gay JM, Buechel D, Hauert B, Moreno E (2015) Elimination of unfit cells maintains tissue health and prolongs lifespan Cell
     
  • Merino MM, Rhiner C, Portela M, Moreno E (2013) "Fitness fingerprints" mediate physiological culling of unwanted neurons in Drosophila Curr. Biol.
     
  • Moreno, E. (2012) Design and Construction of ‘‘Synthetic Species’’ PLoS ONE
     
  • Rhiner C, López-Gay JM, Soldini D, Casas-Tinto S, Martín FA, Lombardía L, Moreno E (2010) Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila Dev. Cell
     
  • Portela M, Casas-Tinto S, Rhiner C, López-Gay JM, Domínguez O, Soldini D, Moreno E (2010) Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition Dev. Cell
     
  • Moreno, E. (2008) Is cell competition relevant to cancer? Nat. Rev. Cancer
     
  • Moreno E, Basler K (2004) dMyc transforms cells into super-competitors Cell
     
  • Moreno E, Basler K, Morata G (2002) Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development Nature