Joao Pedro Pereira
Date: March 28, 2019. 12:00
Location: CCU Seminar Room
Title: How to make and when not to make B cells
Affiliation: Yale School of Medicine, USA
Immune cells are produced at rates that ensure the homeostasis of individual immune cell lineages, but upon systemic infection and/or inflammation, priority is given to the production of short-lived and fast-acting myeloid cells, at the expense of the production of longer-lived and slower-acting lymphocytes. The molecular mechanisms underlying these decisions are largely unknown. In this seminar I will overview studies that led to the identification of specialized microenvironments in bone cavities that control the development of lymphocytes. I will also describe unpublished findings that explain mechanistically how (and why) systemic infection and inflammation resets priorities to promote myeloid cell development at the expense of lymphoid cell development. Finally, I will discuss recent and preliminary findings indicating that lymphoid leukemias exploit these mechanisms to prioritize leukemic cell proliferation at the expense of non-leukemic blood cell production.