Date: May 23, 2019. 12:00
Location: CCU Seminar Room
Title: Correlating structure and function in the mammalian retina and beyond
Affiliation: Center of Advanced European Studies and Research (CAESAR), Germany
We explored multiple forms of wiring specificity in the mammalian retina by combining different types of functional imaging with subsequent reconstruction of synaptic connectivity. Focusing on the circuit that computes the direction of motion across the retina, we have identified specific wiring arrangements between excitatory neurons (bipolar cells) and interneurons (amacrine cells), amongst interneurons (amacrine cells), and between interneurons and the projection cells of the retina (retinal ganglion cells). Each of these wiring arrangements support the computation of direction selectivity and enable the computation to be robust to wide ranges of contrasts and velocities. By comparing wiring differences between species (mouse vs. rabbit) we also constructed computational network models to address which aspects of the computation generalize across species and which are species specific. Finally, I will discuss our ongoing work to carry this approach (i.e., correlating large-scale functional imaging and EM-based connectivity mapping to constrain models) forward to whole brain imaging in fish.