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Adriano Aguzzi (Clinical Seminar)

  1. Date: December 05, 2019. 14:00
    Location: CCU Seminar Room

    Title: Drivers of neurotoxicity in prion diseases

    Affiliation: Director, Institute of Neuropathology, University of Zurich.

    Abstract:

    Many proteins can self-assemble into highly-ordered fibrillary aggregates called amyloids, which are responsible for a number of human diseases including Alzheimer’s, Parkinson’s and systemic amyloidoses. The mechanisms of amyloid assembly is relatively well-understood, yet the downstream events leading to toxicity are largely unknown. My lab studies these phenomena using prions, infectious self-replicating protein-only particles causing transmissible spongiform encephalopathies. In my seminar, I will discuss the molecular events underlying prion toxicity and highlight possible therapeutic strategies.

  2. Host:


    Thiago Carvalho