Date: November 21, 2019. 12:00
Location: CCU Seminar Room
Title: Morphogenesis of proliferative tissues: scaling between mechanical stress and proliferation.
Affiliation: Institut Curie, France
Questions related to embryo shape or morphogenesis have haunted developmental biologists for decades. Recent advances in imaging, cell biology, signal transduction and biophysics have framed the study of tissue morphogenesis in terms of collective cell dynamics and the interplay between biochemical and mechanical processes.
Recent findings have confirmed that proliferative epithelial tissues reshape via morphogenetic processes such as cell shape change and cell rearrangements. Yet cell division remodels adherent junctions and modulates both tissue mechanics and tissue dynamics. Therefore its role and interplay with the other morphogenetic processes need to be understood to decipher the mechanisms of tissue morphogenesis. During my talk, I will describe some of our latest works that aim to understand the mechanisms by which cells scale their response to mechanical stress to ensure proper epithelial morphogenesis.