Date: November 14, 2019. 12:00
Location: CCU Seminar Room
Title: An experience dependent comparator circuit in layer 2/3 of mouse cortex
Affiliation: Friedrich Miescher Institute for Biomedical Research(FMI), Switzerland
I will argue that the computational function of layer 2/3 of mouse cortex is that of a comparison between predicted and actual input. In visual cortex, this is a comparison between bottom up visual input and a top-down prediction of visual input given movement, spatial location and surrounding visual context. This comparison is shaped by experience and gives rise to positive and negative prediction error signals which are thought to update an internal representation of the visual scene in visual cortex. One of the key questions for us currently is whether these functionally defined classes of positive and negative prediction error neurons have molecular markers that can be experimentally leveraged to probe the local cortical circuit. I will present some preliminary data to argue that this might indeed be the case.