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Jonathan Kipnis

  1. Date: October 15, 2018. 11:00
    Location: CCU Seminar Room

    Title: Immune system – the seventh sense

    Affiliation: University of Virginia School of Medicine, USA

    Abstract:

    Immune cells and their derived molecules have major impact on brain function. Mice deficient in adaptive immunity have impaired cognitive and social function compared to that of wild-type mice. Importantly, replenishment of the T cell compartment in immune deficient mice restored proper brain function. Despite the robust influence on brain function, T cells are not found within the brain parenchyma, a fact that only adds more mystery into these enigmatic interactions between T cells and the brain. Our results suggest that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. We have recently discovered a presence of meningeal lymphatic vessels that drain CNS molecules and immune cells to the deep cervical lymph nodes. This communication between the CNS and the peripheral immunity is playing a key role in several neurological and psychiatric disorders and, therefore, may serve as a novel therapeutic target that is worth in-depth mechanistic exploration.

    Lab website

  2. Host:


    Basma Husain