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Alex Schier

  1. Date: September 26, 2019. 12:00
    Location: CCU Seminar Room

    Title: Cellular Biographies: Reconstructing Developmental Trajectories

    Affiliation: Harvard University, USA.


    Complex gene expression programs determine the biographies of cells: how a cell divides, becomes specialized and differentiates. I will describe our recent efforts to use single-cell RNA sequencing and CRISPR-Cas9 genome editing to generate new tools to reconstruct differentiation trajectories and lineage trees at very large scales. Using mesoderm and brain development as examples, I will discuss the opportunities and challenges for these technologies to reveal the developmental biology of cells (also see McKenna et al. Science 2016; Farrell et al. Science 2018; Raj et al. Nature Biotechnology 2018).

    Lab webpage

  2. Host:

    Antonia Groneberg