Tor Erik Rusten
Date: April 26, 2018. 12:00
Location: CCU Seminar Room
Affiliation: Oslo University Hospital, Norway.
We study the cellular mechanisms of how epithelial tumors develop and interact with the organism to cause cancer.
We combine the use of human cells in culture and the animal model, Drosophila melanogaster to pursue two broad questions:
- What cellular processes and mechanisms underlie the deconstruction of epithelia and cellular transformation in response to mutations in proto-oncogenes or tumor suppressors?
- How does tumor cells interact with and impact the organism? Tumor cells depend on the organism (patient) for its growth and reciprocally have widespread impact on physiology and survival.
We seek to mechanistically decipher these interactions with microenvironmental cells and somatic tissues.