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Research Technician Position

  1. Date: 16.5.2019
  2. Location: Champalimaud Centre for the Unknown, Lisbon - Portugal
  3. Employer: Champalimaud Foundation
  4. Job type: Full Time
  5. Position: Technical
  6. Application start: 16.5.2019             Application ends: 10.6.2019

  7. Do you want to know more about the neural basis of behavior, and more particularly about the role of neuromodulators in the regulation of decision-making and learning? Are you interested in studying the neuropharmacological properties of some of the most common treatments used to alleviate psychiatric disorders? Do you want to contribute to our efforts to better understand the mode of action of innovative therapies targeting the serotonin system? We may be looking for you!

    The Position

    We are opening a technician position at the System Neuroscience lab, to be part of a collaborative project aiming at studying the fine-grained behavioral effects of a panel of drugs acting on the serotonergic system. The pharmacological manipulations will be performed either acutely or chronically and the behavioral assessments will rely on several paradigms already developed or under development in the lab, with an emphasis on the neurocomputational mechanisms underlying foraging and exploration.

    In a young and dynamic team, you will have the opportunity to interact with highly experienced researchers coming from different backgrounds and cultivating original perspectives on brain, behavior and cognition. You will work closely with other team members from whom you will receive the training needed to perform successfully the following tasks:

    ~Mice handling and training in different behavioral protocols;
    ~Systemic or local (i.e. intracranial) drug administration;
    ~Data handling and analysis;
    ~Participation in the scientific life of the team (lab meetings, journal clubs, seminars, conferences, etc).

    The Project

    A better understanding of the mode of action of drugs currently used in psychiatry is essential to foster therapeutic innovations as well as progress in fundamental neuroscience. A major focus of our team is to study serotonin, one of the most complex and ubiquitous signaling system of the mammalian brain. Using a combination of system neuroscience techniques and highly innovative behavioral assays, we aim at deciphering the computational role of serotonergic signals, their impact on behavior and the control mechanisms which govern their expression in the murine brain.
    More recently, we started to apprehend this system “translationally” by developing homologous behavioral paradigms in both mice and humans. The current project represents a new step towards a better integration of rodent and human data regarding the mode of action and the behavioral consequences of various drugs acting on the 5-HT system, such as antidepressant, anxiolytic, antipsychotic and psychedelic compounds.

    The Candidate

    Any national, foreign and stateless candidate holding a Bachelor’s degree.

    Essential qualifications

    ~ Bachelor’s degree in engineering, neuroscience, biology or other research areas relevant to animal behavior;
    ~ Certificate on Laboratory Animal Sciences, ideally according to FELASA recommendations for Cat. B;
    ~ Experience with animal handling and training in behavioral paradigms;
    ~ Good organizational skills, rigor and precision;
    ~ Good capacity and value for teamwork;
    ~ Fluency in English and willingness to work in an international environment.*

    Additional optional qualifications

    ~ Experience with histology, molecular biology and pharmacology;
    ~ Programming skills are welcome (e.g. R, Julia, Matlab, Python).

    To Apply
    Submit a single document (paper or PDF) that contains a motivation letter and CV, both written in English, collectively not exceeding 4 pages. Applications can be sent by email, with subject “RT2019 5HTNAC YourLastName”, to the email address careers@research.fchampalimaud.org.

    Applications are also accepted in paper, sent or handed to the HR & Fellows Support Office at the Champalimaud Centre for the Unknown. For more information please check the eracareers call here.

Latest Publications

  • Rao-Ruiz, Priyanka; Couey, Jonathan J.; Marcelo, Ivo M.; Bouwkamp, Christian G.; Slump, Denise E.; Matos, Mariana R.; van der Loo, Rolinka J.; Martins, Gabriela J.; van den Hout, Mirjam; van IJcken, Wilfred F.; Costa, Rui M.; van den Oever, Michel C.; Kus (2019) Engram-specific transcriptome profiling of contextual memory consolidation Nat Commun
  • French, Catherine A.; Vinueza Veloz, Maria F.; Zhou, Kuikui; Peter, Sasa; Fisher, Simon E.; Costa, Rui M.; De Zeeuw, Chris I. (2019) Conditional disruption of Foxp2 in the mouse brain Mol. Psychiatry
  • Riahi, Human; Brekelmans, Carlijn; Foriel, Sarah; Merkling, Sarah H.; Lyons, Taylor A.; Itskov, Pavel M.; Kleefstra, Tjitske; Ribeiro, Carlos; van Rij, Ronald P.; Kramer, Jamie M.; Schenck, Annette (2019) The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption PLoS Biol.
  • Inês Santiago, João Santinha, Andrada Ianus, Antonio Galzerano, Rita Theias, Joana Maia, Maria Joao Barata, Nuno Loução, Bruno Costa-Silva, Antonio Beltran, Celso Matos and Noam Shemesh (2019) Susceptibility perturbation MRI (SPI) maps tumor infiltration into mesorectal lymph nodes Can Res
  • Rodriguez-Ruiz, Claudia; Munoz-Reyes, Jose Antonio; Iglesias-Julios, Marta; Sanchez-Pages, Santiago; Turiegano, Enrique (2019) Sex Affects the Relationship Between Third Party Punishment and Cooperation Sci Rep