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Call for (2) Postdoctoral Fellows in the Systems Oncology lab

  1. Date: 18.12.2017
  2. Location: Champalimaud Centre for the Unknown, Lisboa, Portugal
  3. Employer: Champalimaud Foundation
  4. Job type: Full Time
  5. Position: Postdoctoral Positions
  6. Application start: 18.12.2017             Application ends: 2.3.2018

  7. 2 (two) fully-funded post-doc positions are available immediately in the Systems Oncology Lab Champalimaud Centre for the Unknown in Lisbon, Portugal. We are looking for a top-tier, motivated Post-Doctoral Fellow with a strong interest in investigating cancer as a focus is on identifying extracellular vesicles subpopulations relevant for tumor biology flow cytometry. In particular, we aim to hire one person with extensive experience in animal experimentation.

    To apply, please send the following items to: bruno.costadasilva@research.fchampalimaud.org
    1. Cover Letter stating your interests
    2. A full CV, including list of publications
    3. Names and email addresses of 3 references.
    Successful applicants will receive full funding.
    Call deadline: Mar 2 nd 2018.

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    The general interest of the Systems Oncology group is to understand how non-tumor cells contribute to tumor initiation, growth and metastasis. More than focusing on specific tumor types, the projects in the group aim in investigating the biological systems that support oncologic disease. For instance, by releasing soluble factors and/or extracellular vesicles, tumor cells can induce phenotypic modifications of stromal cells locally and at future sites of tumor dissemination (also known as pre-metastatic niches),
    which support tumor growth and metastasis. Extracellular vesicles isolated from liquid biopsies (such as plasma and other body fluids) are emerging as a powerful non-invasive and abundant source of information not only about tumor cells, but also potentially about how non-tumor cells respond/interact with malignant cells. By using animal models of tumor initiation, progression and metastasis, in combination with thorough analysis of extracellular vesicle composition isolated from patients with diverse clinical profiles, we intend to characterize novel cellular and molecular determinants of cancers.

    The Systems Oncology Lab is equipped with two ultracentrifuges for exosomes isolation, a Nanosight NS300 for analysis of exosomes concentration and size distribution, a state-of- the-art nanoparticle flow cytometer analyzer Apogee A60-Micro- PLUS and an Odyssey CLx for whole organ analysis of exosomes distribution. The Systems Oncology group further benefits from full access to all Champalimaud Research Platforms, including: a state-of- the-art Vivarium, including access to a fully-functional surgery room dedicated to the animal experimentation performed by the Systems Oncology group; Molecular Biology; Histology; Optical Imaging; and Custom Hardware and Software Development.

    The Champalimaud Centre for the Unknown, a private, non-profit foundation provides a stunning and productive working environment, combining basic research and clinical practice under the same roof, which actively encourages collaborations and exchange of ideas and results in a highly interdisciplinary and stimulating atmosphere. Post-Doctoral salaries are very competitive vis-à-vis Lisbon costs of living.

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